Calibration of Quality-Adjusted Life Years for Oncology Clinical Trials
نویسندگان
چکیده
منابع مشابه
Weighting components of composite end points in clinical trials: an approach using disability-adjusted life-years.
BACKGROUND AND PURPOSE Conventional analysis of vascular prevention trials assigns equal weight to disparate vascular events in a composite end point at variance with the public's perception of their differential impact on health outcome. This study sought to apply the disability-adjusted life-year (DALY) metric to differential weighting individual vascular end points in trial analyses. METHO...
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Quality of life (QoL) has become an accepted and widely used endpoint in clinical trials. The analytical tools used for QoL evaluations in clinical trials differ from those used for the more traditional endpoints, such as response to disease, overall survival or progression-free survival. Since QoL assessments are generally performed on self-administered questionnaires, QoL endpoints are more p...
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The quality-adjusted life-year (QALY) is a measure of the value of health outcomes. Since health is a function of length of life and quality of life, the QALY was developed as an attempt to combine the value of these attributes into a single index number. The QALY calculation is simple: the change in utility value induced by the treatment is multiplied by the duration of the treatment effect to...
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ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 2014
ISSN: 0885-3924
DOI: 10.1016/j.jpainsymman.2013.07.016